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Indomethacin 25 mg capsule 4 g/8 h 7 5 0.33 0.67, 1.00 0–5 y 6.2 g/d (range: 2.0–8.5 g/d) 3.2–11.2 4.7–10.4 3.2–10.0 5–10.4 >10.4 Open in a separate window We used all data in our meta-analyses. The main effects were statistically significant for the low-dose intervention (odds ratio 2.3 [95% CI, 1.1–4.3]; P<0.0001) and the high-dose intervention (1.8 [95% CI, 1.4–2.5]; P<0.0001). Results from the subgroup analyses (n=3,912) were consistent with the main effects. heterogeneity was also high, χ2 = 19.9 (Q1, 97 to 105) (Q2, 104), with 17 studies including the low-dose arm of intervention and 11 studies included the buy indometacin uk high-dose arm. summary relative risk of all-cause mortality with low-dose intervention in a subgroup of 5,500 participants (10,564 total person-years of follow-up) was 0.77 (95% CI, 0.68–0.84), and among participants with a low baseline risk of mortality (HR, 0.70; 95% CI, 0.51–0.90), the summary relative risk was 0.85 (95% CI, 0.73–0.96) for the low-dose group and 0.91 (95% CI, 0.88–0.96) for the high-dose group. DISCUSSION This meta-analysis names for drug store of seven randomized trials showed a substantial benefit of low-dose aspirin regimen in increasing the risk of all-cause mortality, mainly with respect to the elderly (age >65 years). benefits were seen in both the elderly and young (>15–34 years), irrespective of whether the intervention was low dose (approximately 100–150 mg/d) or high dose (300–500 mg/d), and irrespective of whether aspirin was added to usual care or not. Similar analyses of the meta-analysis a low-dose intervention with similar treatment guidelines as the current resulted in a nonsignificant reduction all-cause mortality (HR, 0.97 [95% CI, 0.94–1.01]). The current low-dose guidelines recommend 400 mg/d of aspirin in patients >65 years old to maintain cardiovascular health against diseases, and 150 mg/d to patients with cardiovascular disease (see ). In our meta-analysis, when both low- and high-dose intervention are taken into account, the benefits were slightly decreased (0.72 [95% CI, 0.63–0.80]). Furthermore, we found a high heterogeneity among trials, especially trials with a small number of participants (n=3,912) as well when the intervention was low and high doses ( ). However, the heterogeneity was not as high (31% or 35%). The benefits were not evident in the elderly regardless of whether aspirin was added to usual care. In the studies with a high number of participants (n=4,082), the benefit was found mainly in the high-dose group, and no benefit in the low-dose group was seen. In the studies including participants with a low.